In recent years, the use of CHM has increased in the Western world, although the mechanism by which CHM improves sleep remains undefined ( Frass et al., 2012 Leach and Page, 2015). The importance of CHM is evidenced by approval in the latest evidence-based guidelines in China for insomnia ( Liu, 2011.). Recently, traditional Chinese medicine (TCM) has been found to be an effective complement and alternative for treating insomnia ( Yeung et al., 2012 Ng and Parakh, 2021).Ĭhinese herbal medicine (CHM), as either single herbs or herbal formulas, has been widely used for the treatment of insomnia in China. However, none of these therapies is effective in the long term because of the difficulty of effective implementation or limitations of efficacy and adverse reactions. Therefore, the treatments of insomnia can be complex and time consuming and mainly include behavioural, cognitive, and Western pharmacological interventions (such as benzodiazepine receptor agonists) ( Buysse, 2013 Kay-Stacey and Attarian, 2016). The aetiology and pathophysiology of insomnia are complex and involve genetic, environmental, behavioural, and physiological factors ( Buysse, 2013). Clinical epidemiological studies have suggested that insomnia is associated with hypertension, stroke, depressive disorders, psychotic disorders, dementia, substance abuse disorders and weakened immunity ( Yin et al., 2017 Sanjari Moghaddam et al., 2021). Insomnia is the most common sleep problem in the general population and seriously affects not only people’s physical and mental health but also their quality of life and work efficiency ( Patel et al., 2018 Sutton, 2021). The development of large-scale trials with longer follow-up durations is recommended to provide further evidence.Ĭlinical Trial Registration:, identifier ChiCTR1800019239 In terms of safety, JTW had no noticeable adverse effects relative to placebo.Ĭonclusion: JTW was effective and well tolerated for the treatment of ISDHK. There were significant posttreatment differences in metabolites in the left cerebellum between the two groups (myoinositol: JTW, 13.47 ± 2.094 vs. Serum melatonin was increased in patients with ISDHK after JTW treatment (JTW, 339.09 ± 256.894 vs. Higher CGI and lower DHKSS scores were observed after JTW treatment. However, no PSG changes were observed between the two groups ( p > 0.05). Symptom relief was more apparent in the JTW group than the placebo group (PSQI total score: 9.34 ± 3.578 vs. Results: A total of 106 participants completed this clinical trial. ![]() All data were collected at baseline and posttreatment. Laboratory tests were used to evaluate the safety of JTW. ![]() Pittsburgh Sleep Quality Index (PSQI) scores were set as the primary outcome, and polysomnography (PSG), 1H-magnetic resonance spectroscopy ( 1H-MRS), blood tests, and Disharmony of Heart and Kidney Scoring System (DHKSS) and clinical global impression (CGI) scores were used as secondary outcomes. for 7 days) or placebo group (2-g placebo granules, b.i.d. All participants were equally and randomly divided into either the JTW group (2-g JTW granules, b.i.d. Methods: From September 2018 to February 2020, 128 participants with ISDHK were included in this single-center clinical trial. This study aimed to evaluate the effectiveness and safety of JTW for treating ISDHK in a double-blind, randomized, placebo-controlled trial.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |